Suppressor of Melanoma Tumor Growth
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April 28, 2009
A gene that suppresses tumor growth in melanoma has been identified by researchers at the National Institutes of Health (NIH). The gene, known as matrix metalloproteinase-8 (MMP8), could pave the way for new individualized therapies for melanoma, write the authors of a new study that was published online March 29 in Nature Genetics...[read article]
Pioglitazone With Acitretin Safea nd Effective for Chronic Plaque-Type Psoriasis
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April 28, 2009
Pioglitazone may offer a convenient, efficacious, and relatively safer alternative for combination with the synthetic retinoid acitretin than currently available immunosuppressive agents in treating patients with chronic plaque-type psoriasis, according to the results of a randomized, placebo-controlled trial reported in the April issue of the Archives of Dermatology..[read article]
Penciclovir Cream Appears to Permeate Skin Better Than Acyclovir
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April 18, 2009
In a side-by-side in vitro study, penciclovir 1% cream yielded a higher concentration of drug in the deeper layers of epidermis than did acyclovir 5% cream..[read article]
Eczema In Children Is Increasing, But Diet Is Not The Cause
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March 21, 2009
The number of children who have eczema has risen – one in five children are now affected by this skin condition, which is often associated with an allergy. Researchers are not yet sure what is causing this growing problem. Many people believe that certain foods are responsible, or at least make the symptoms worse..[read article]
Low-Dose Acitretin Therapy Reduces Nail Psoriasis
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March 20, 2009
Low-dose acitretin therapy is effective in treating isolated nail psoriasis, according to a study published in the March issue of the Archives of Dermatology. In addition, the use of this systemic therapy was both well-tolerated and produced lasting results after the termination of the treatment phase..[read article]
Calcitriol Maintains Suppression of Psoriasis
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March 18, 2009
Calcitriol ointment as adjunctive therapy to topical steroids is beneficial in continuing to suppress the re-emergence of plaque psoriasis. The research, based on analysis of the first 150 of 300 patients to complete the regimen, was presented here at the American Academy of Dermatology 67th Annual Meeting..[read article]
Highly Active Antiretroviral Therapy Enhances Human Papillomavirus Clearance
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FEB 25, 2009
Highly active antiretroviral therapy (HAART) enhances clearance of human papillomavirus (HPV) in HIV-infected women with abnormal Pap tests, according to a report in the January issue of Obstetrics & Gynecology...[read article]
FDA Not Effectively Monitoring Investigator Conflicts of Interest, HHS
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FEB 24, 2009
More than one third of new drug marketing applications approved by the US Food and Drug Administration (FDA) were missing information about potential conflicts of interest for clinical trial investigators, which could allow bias to creep into the approvals process ...[read article]
FDA Alert on Safety of Topical Anesthetics
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FEB 23, 2009
The Food and Drug Administration (FDA) today released a public-health advisory underlining potential life-threatening adverse events from the improper use of topical anesthetics.
Improper use includes applying too much, over too large an area, application to broken or ...[read article]
Cefuroxime Superior to Penicillin for Pediatric Perianal Streptococcal Dermatitis
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FEB 22, 2009
Cefuroxime was more effective than penicillin in a Swiss study for the treatment of perianal Streptococcal dermatitis in children "and therefore should be considered as the treatment of choice," the investigators say.
In their paper in the December issue of The Journal of Pediatrics, the researchers cite a report indicating that perianal ..[read article]
Associate Psoriasis With Specific Genes and Pathways
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FEB 19, 2009
Three genomewide studies have identified gene variants and pathways associated with an increased risk for psoriasis. The reports, published online yesterday in Nature Genetics, suggest that disrupting the normal skin barrier increases susceptibility to ..[read article]
Low Estrogen Receptor Expression in Melanoma Reflects Poor Prognosis
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FEB 18, 2009
Low levels of estrogen receptor (ER) expression appear to indicate a higher potential for metastasis of cutaneous melanoma lesions, Italian researchers reportDr. Vincenzo de Giorgi and colleagues at the University of Florence...[read article]
Primary Care Management of Skin Pigmentation Disorders Reviewed
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FEB 15, 2009
Although most pigmentation disorders are benign or nonspecific, some disorders of skin pigmentation present cosmetic or psychological challenges to the patient, necessitating evaluation and treatment," write Scott Plensdorf, MD, from Michigan State University College of ...[read article]
Blood Pressure Drugs Linked to Protection Against Non-Melanoma Skin Cancer
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FEB 13,2009
ACE inhibitors and angiotensin receptor blockers were associated with a 33% to almost 40% reduced risk of basal-cell or squamous- cell carcinoma in high-risk U.S. veterans, Jennifer B. Christian, Pharm.D., Ph.D., of Brown University here, and colleagues reported in the Aug. 26 online issue of the Journal of the National Cancer Institute....[read article]
FDA Approves Updated Labeling For Psoriasis Drug Raptiva
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FEB 10, 2009
The U.S. Food and Drug Administration today announced labeling changes, including a Boxed Warning, to highlight the risks of life-threatening infections, including progressive multifocal leukoencephalopathy (PML), with the use of Raptiva (efalizumab). The labeling changes are based on the FDA's post-market ...[read article]
