Mumbai-Based Company Gets Tentative Approval for Generic Ezetimibe
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April 29, 2009
The US Food and Drug Administration has granted tentative approval to Glenmark Pharmaceuticals Ltd to sell a generic version of the cholesterol-lowering medication ezetimibe.....[read article]
Reducing LDL Cholesterol With Statins
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April 19, 2009
Reducing LDL-cholesterol levels with statins is effective in reducing initial and recurrent stroke, according to an updated meta-analysis [1]. Data from 24 randomized clinical trials showed that lipid lowering with statins cut the risk of stroke by one-fifth compared with controls, report investigators....[read article]
PDA-Based Support Improves Appropriate ATP III Cholesterol Treatment
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April 19, 2009
Interestingly, the PDA-based intervention led to a decrease in overtreatment--that is, a reduction in prescribing cholesterol-lowering medications to patients who did not need them...[read article]
LDL Cholesterol Levels Lowest in Summer, Highest in Winter
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April 13, 2009
The emergence of the summer sun after a long winter appears to have a positive effect on lipid levels, a new analysis has shown [1]. On-treatment LDL-cholesterol levels, regardless of the intensity of statin therapy, are significantly lower in summer than in winter, report investigators...[read article]
Dietary Fiber Beneficial for Adults With and Without Hypercholesterolemia
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April 06, 2009
The routine use of soluble fibers may be indicated in the diets of adult patients with and without hypercholesterolemia, according to the results of a meta-analysis reported in the March/April issue of the Annals of Family Medicine....[read article]
Hypertriglyceridemia Is Common Among US Adults
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April 02, 2009
Hypertriglyceridemia is common among US adults and should be treated with lifestyle change in most cases, according to the results of a study reported in the March 23 issue of the Archives of Internal Medicine...[read article]
Lisinopril, Valsartan Seen Superior in Reducing Pulse Pressure
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March 12, 2009
Lisinopril and valsartan, with or without hydrochlorothiazide, are more effective in reducing pulse pressure than are a number of other agents, Turkish researchers report in the spring issue of Cardiovascular Therapeutics...[read article]
UK Guidelines Address Care of Fertile Women With Familial Hypercholesterolemia
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March 11, 2009
Guidelines for the management of fertility in women with familial hypercholesterolemia (FH), issued by the UK National Institute for Health and Clinical Excellence (NICE), are reported in the March BJOG: An International Journal of Obstetrics and Gynaecology...[read article]
Cholesterol-Lowering Drugs in HIV
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March 08, 2009
One of the largest studies to date to assess the safety and efficacy of cholesterol-lowering drugs in HIV-infected people shows that statins and fibrates produce clinically meaningful improvements in lipid profiles but that these drugs may not be quite as effective in this group as they are in HIV-uninfected individuals...[read article]
Six New Loci Associated With Serum Lipid Levels
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FEB 25, 2009
in international genomewide association study has identified 6 genetic loci associated with serum lipid levels in European populations. This brings to 22 the total number of genomic regions affecting serum lipid levels, a major risk factor in cardiovascular disease. The study, presented here at the American Society of Human Genetics 58th Annual Meeting, is part of the ENGAGE Consortium, an extensive...[read article]
Statins Slow Atherosclerosis in Part Through Non-Cholesterol Factors
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FEB 24, 2009
Mechanisms of action of statins other than lowering cholesterol contribute to reducing the progression of atherosclerosis in arteries, and this has now been demonstrated in patients following coronary artery bypass grafting (CABG), researchers report ...[read article]
LDL Cholesterol Levels Falling, Triglycerides Skyrocketing
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FEB 23, 2009
An analysis of the US National Health and Nutrition Examination Survey (NHANES) database shows that low-density lipoprotein (LDL) cholesterol levels among adult Americans have fallen somewhat since 1980. However, triglyceride levels have nearly quintupled over the same time period...[read article]
High Cholesterol Levels Drop Naturally In Children On High-Fat Anti-Seizure Diet, Hopkins
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FEB 22, 2009
Elevated cholesterol levels return to normal or near normal levels over time in four out of 10 children with uncontrollable epilepsy treated with the high-fat ketogenic diet, according to results of a Johns Hopkins Children's Center study reported in the Journal of Child Neurology. The study appears online ahead of print...[read article]
Lower Total Cholesterol Level Tied to Higher In-Hospital CHF Mortality
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FEB 21, 2009
In patients hospitalized with acute decompensated congestive heart failure, low total cholesterol levels independently predict a higher risk of in-hospital death, a report in the December issue of the American Heart Journal shows...[read article]
Lipoprotein Particles More Indicative of Cardiovascular Risk Than LDL Cholesterol
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FEB 20, 2009
Risk of cardiovascular disease can remain high even after low-density lipoprotein (LDL) cholesterol target levels have been reached in patients with the metabolic syndrome. Risk may be better gauged with low-density lipoprotein particle concentration, investigators announced here at the American Heart ...[read article]
Issues On Cholesterol: Diet, Statins And Genetics
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FEB 19, 2009
Genetic lipoprotein disorders are frequently seen in patients with premature coronary artery disease (CAD). An example of strong genetic predisposition is the disorder: familial hypercholesterolemia, where a single gene defect (the low density lipoprotein receptor) contributes to most of the familial expression of CAD...[read article]
Survey Among European Cardiologists Points To A Gap In Cardiovascular Disease Management
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FEB 17, 2009
Cardiologists in Europe agree that reducing LDLcholesterol (LDL-C or "bad" cholesterol) is the most important consideration when treating dyslipidaemia (abnormal blood lipids). A majority of cardiologists also agree that in addition to lowering LDL-C, raising HDL-cholesterol (HDL-C or "good" cholesterol) and reducing triglycerides are..[read article]
Lipitor 80 Mg Provided Sustained Risk Reduction Of Cardiovascular Events In Patients With Heart Disease During The Five-Year TNT Trial
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FEB 15, 2009
Pfizer announced that in patients with established heart disease, Lipitor® (atorvastatin calcium) 80 mg not only significantly reduced the relative risk of suffering a first cardiovascular event by 19 percent compared to Lipitor 10 mg but also provided a sustained reduction in the risk of a subsequent second, third, fourth, and fifth cardiovascular event....[read article]
Lipid-Lowering Therapies And Cardiovascular Disease Prevention
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FEB 20, 2009
Strategies for cardiovascular disease (CVD) prevention using lipid-lowering medications can be improved by adopting the absolute-risk approach, according to a research paper in the latest issue of the Medical Journal of Australia..[read article]
