Lapatinib Shows Activity Against Inflammatory Breast Cancer
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April 29, 2009
New research suggests that lapatinib, an inhibitor of epidermal growth factor receptor tyrosine kinases, may be an effective treatment for HER2-overexpressing relapsed or refractory inflammatory breast cancer....[read article]
Lower Survival With Primary Breast Non-Hodgkin's Lymphoma
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April 16, 2009
Women with primary breast non-Hodgkin;s lymphoma (PBL) have lower survival than do individuals with aggressive nodal lymphomas, according to a report in the March issue of the American Journal of Hematology...[read article]
Triple-Negative Breast Cancers Are Increased in Black Women
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April 16, 2009
Triple-negative breast cancers (negative for estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HER2]), are 3-fold more common in black women than in nonblack women, regardless of age or body mass index (BMI), according to the results of a study reported in the March 25 issue of Breast Cancer Research...[read article]
Guidelines for Breast Cancer Updated
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March 20, 2009
Genetic counseling is now recommended for women with either ductal carcinoma in situ or early invasive breast cancer when genetic testing indicates a high risk for hereditary breast cancer, said Beryl McCormick, MD, from the Sloan-Kettering Cancer Center, in New York City, in a presentation here at the National Comprehensive Cancer Network (NCCN) 14th Annual Conference..[read article]
Estrogen/Progesterone Combo Doubles Lobular Breast Cancer Risk
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March 20, 2009
Postmenopausal use of a combination of estrogen and progesterone more than doubles the risk of lobular breast cancer and nearly doubles the risk of ductal breast cancer, while estrogen alone does not increase risk, according to a report from the American Cancer Society ..[read article]
Hypertension Partially Explains Racial Disparity in Breast Cancer Survival
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March 13, 2009
High blood pressure accounts for some of the disproportionately higher mortality rates among African American patients with breast cancer compared with Caucasian patients, according to an article in the International Journal of Cancer for March ..[read article]
Taxane Superior to Anthracycline in Early Breast Cancer, But Best Usage Uncertain
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March 08, 2009
New long-term results from a study in early breast cancer showing superiority of a taxane combination have again stirred controversy about the continued use of anthracyclines in this setting. But the trial leaves many questions unanswered..[read article]
Risk Factors Warranting Contralateral Prophylactic Mastectomy for Breast Cancer Identified
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FEB 25, 2009
Risk factors that may warrant contralateral prophylactic mastectomy (CPM) for breast cancer have been identified, according to the results of a study reported in the January 26 Online First issue of Cancer...[read article]
Meaning and Depression in Breast Cancer
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FEB 25, 2009
Higher levels of symptom distress in women with breast cancer predict higher levels of anxiety and depression, which often coexist in these patients, according to a study presented at the 22nd Annual Meeting of the American Psychiatric Nurses Association..[read article]
Neoadjuvant Ixabepilone Promising Against Breast Cancer
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FEB 24, 2009
Neoadjuvant monotherapy with ixabepilone can be effective in certain patients with invasive breast cancer.
Among predictors of a complete clinical response are estrogen-receptor (ER) gene expression and the microtubule-associated protein tau...[read article]
Fruit and Vegetable Intake Among Adolescents and Adults in the United States: Percentage Meeting Individualized Recommendations
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FEB 23, 2009
Context: Fruit and vegetable intake is an important part of a healthy diet and is associated with numerous positive health outcomes. MyPyramid provides recommendations for fruit and vegetable consumption based on individual calorie requirements as determined by an...[read article]
Ki67 Biomarker in Bladder Cancer May Lead to Improved Outcomes
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FEB 22, 2009
Measuring the biomarker Ki67 in patients with bladder cancer may help improve outcomes in these patients, say researchers.
A multicenter trial of 713 patients has validated the predictive role of the marker, and now a prospective trial of 300 patients is...[read article]
Overexpression of HER-2 Not Prognostic in Colorectal Cancer
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FEB 21, 2009
In patients with colorectal cancer, overexpression of human epidermal growth factor receptor-2 (HER-2) is not a predictor of outcome, according to findings reported by Irish researchers in the online journal BMC Cancer ...[read article]
Insufficient Evidence for Tumor Gene-Expression Profile Products in Breast Cancer
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FEB 20, 2009
There is insufficient evidence to make a recommendation either for or against the use of 3 tumor gene-expression profile products to improve outcomes in defined populations of women with breast cancer, concludes a working group supported by the US Centers for Disease Control and Prevention (CDC)...[read article]
ARF1 Regulates Breast Cancer Cell Growth and Invasion
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FEB 18, 2009
ADP-ribosylation factor 1 (ARF1) regulates breast cancer cell growth and invasion by controlling the activation of the phosphatidylinositol 3-kinase (PI3K) pathway, according to a report by Canadian researchers in the December 26, 2008 issue of The Journal of Biological Chemistry...[read article]
Estrogen Plus Testosterone Not Significantly Related to Breast Cancer Risk
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FEB 17, 2009
study published in the January 12th issue of the Archives of Internal Medicine found a modest but insignificant increase in the rate of invasive breast cancer among users of estrogen plus testosterone (E + T) compared to women not receiving hormone therapy....[read article]
Black Women's Breast Cancer Disparities Related To Inadequate Health System, Opinion
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FEB 15, 2009
black women's "increased vulnerability to breast cancer is a result of differential access to health care and health services," Julianne Malveaux, president of Bennett College for Women, writes in a Seattle Medium opinion piece. She...[read article]
